合作類(lèi)型：技術(shù) 行業(yè)類(lèi)別: 醫(yī)藥研發(fā) 英國(guó) 過(guò)期時(shí)間：2017年05月17日
一家英國(guó)的生物技術(shù)公司提供無(wú)版權(quán)費(fèi)的人類(lèi)化抗體服務(wù)。該公司有超過(guò)13年的抗體綜合開(kāi)發(fā)經(jīng)驗(yàn)以及自己的專(zhuān)利軟件平臺(tái)進(jìn)行健康的、迅速的和準(zhǔn)確的現(xiàn)代CDR移植技術(shù)。該公司正在尋找合作伙伴進(jìn)行技術(shù)協(xié)助下的商業(yè)合作或者技術(shù)合作。
英語(yǔ)原文：
Summary:
A UK biotechnology company is offering royalty free antibody humanization services. The company uses a combination of 13+ years experience in the antibody development industry and their own patented software platform to perform a robust, rapid and accurate modernized version of the traditional CDR grafting technique. They are seeking commercial agreements with technical assistance or technical cooperation agreements
Details:
The company provides royalty free antibody humanization of monoclonal antibodies. Using their next generation insilico CDRx technology they have modernized the traditional Complementarity Determining Region (CDR) grafting technique.
They identify and combine the essential sequences from antibody variable domains into human donor sequences (not germ line) to create a panel of full length humanized antibodies for expression.
Fully humanized monoclonal antibodies are an essential step in the progression of a drug to the clinic and the company's in-house expertise ensures its success. 3, 4 or 5 Vh and Vl sequences can be designed, which gives 9,16 or 25 humanized variant combinations respectively. The more humanized sequences a client opts to design, the more flexibility they will have in choosing a lead candidate with the specific features required.
Affinity is guaranteed within a 2-fold range of the parental antibody (with 16 variants tested by Biacore). The company produces a chimeric antibody at the same time to act as a control and their CDRx process has so far yielded a 100% success rate.
Type and Role of Partners Sought:
The company is looking for partners who have produced murine (rodent family) antibodies and are now seeking humanization of these products as a step towards clinical approvals and marketing.
Cooperation may take the form of a commercial agreement with technical assistance or could also be in the form of a technical cooperation agreement.
